(1S) -CCR2 antagonist 1

(1S) -CCR2 antagonist 1 is a left-handed chiral body of CCR2 antagonist 1 (HY-112792) . CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM[1].

Product Specifications

CAS Number

[1683534-97-5]

UNSPSC

12352005

Target

CCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/1s-ccr2-antagonist-1.html

Purity

98.03

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C([C@]1(C(C)C)C[C@H](N[C@H]2CCC3=C2C=CC(Br)=C3)CC1)N4CC5=C(C=CC(C(F)(F)F)=C5)CC4

Molecular Formula

C28H32BrF3N2O

Molecular Weight

549.47

References & Citations

[1]Vilums M, et al. When structure-affinity relationships meet structure-kinetics relationships: 3- ((Inden-1-yl) amino) -1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists. Eur J Med Chem. 2015 Mar 26;93:121-34.