PD 144418

PD 144418 is a highly affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki values of 0.08 nM and 1377 nM for σ1 and σ2 respectively) . PD 144418 devoids of any significant affinity for other receptors, ion channels and enzymes. PD 144418 shows potential antipsychotic activity[1][2].

Product Specifications

CAS Number

[154130-99-1]

UNSPSC

12352005

Target

Sigma Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pd-144418.html

Purity

98.32

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CCCN1CC(C2=CC(C3=CC=C(C)C=C3)=NO2)=CCC1

Molecular Formula

C18H22N2O

Molecular Weight

282.38

References & Citations

[1]Akunne HC, et al. The pharmacology of the novel and selective sigma ligand, PD 144418. Neuropharmacology. 1997 Jan;36 (1) :51-62.|[2]Lever JR, et al. Relationship between cerebral sigma-1 receptor occupancy and attenuation of cocaine's motor stimulatory effects in mice by PD144418. J Pharmacol Exp Ther. 2014 Oct;351 (1) :153-63.