(2S,3R,4S) -4-Hydroxyisoleucine

(2S,3R,4S) -4-Hydroxyisoleucine is an orally active compound. (2S,3R,4S) -4-Hydroxyisoleucine can be isolated from Trigonella foenum-graecum. (2S,3R,4S) -4-Hydroxyisoleucine has anti-diabetic and anti-diabetic nephropathy activity[1][2][3].

Product Specifications

CAS Number

[55399-93-4]

Product Name Alternative

(2S,3R,4S) -4-Hydroxy-L-isoleucine

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Insulin Receptor

Type

Natural Products

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/2s-3r-4s-4-hydroxyisoleucine.html

Purity

98.0

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

O[C@@H](C)[C@H](C)[C@H](N)C(O)=O

Molecular Formula

C6H13NO3

Molecular Weight

147.17

Precautions

H315, H319, H335

References & Citations

[1]Shi X, et al. Engineering a short-chain dehydrogenase/reductase for the stereoselective production of (2S,3R,4S) -4-hydroxyisoleucine with three asymmetric centers. Sci Rep. 2017 Oct 20;7 (1) :13703.|[2]Broca C, et al. 4-Hydroxyisoleucine: effects of synthetic and natural analogues on insulin secretion. Eur J Pharmacol. 2000 Mar 3;390 (3) :339-45.|[3]Haeri MR, et al. Non-insulin dependent anti-diabetic activity of (2S, 3R, 4S) 4-hydroxyisoleucine of fenugreek (Trigonella foenum graecum) in streptozotocin-induced type I diabetic rats. Phytomedicine. 2012 May 15;19 (7) :571-4.