Tucidinostat-d4

Tucidinostat-d4 is the deuterium labeled Tucidinostat. Tucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, respectively[1].

Product Specifications

Product Name Alternative

Chidamide-d4; HBI-8000-d4; CS 055-d4

UNSPSC

12352005

Target

HDAC; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.63

Solubility

10 mM in DMSO

Smiles

O=C(C1=C([2H])C([2H])=C(CNC(/C=C/C2=CN=CC=C2)=O)C([2H])=C1[2H])NC(C=CC(F)=C3)=C3N

Molecular Formula

C22H15D4FN4O2

Molecular Weight

394.43

References & Citations

[1]Ning ZQ, et al. Chidamide (CS055/HBI-8000) : a new histone deacetylase inhibitor of the benzamide class with antitumor activity and the ability to enhance immune cell-mediated tumor cell cytotoxicity. Cancer Chemother Pharmacol. 2012 Apr;69 (4) :901-9.