8 (S) -HETE

8 (S) -HETE (8 (S) -Hydroxyeicosatetraenoic acid) is a major lipoxygenase product in PMA-treated murine epidermis. It activates mouse keratinocyte protein kinase C with an IC50 of 100 μM. 8 (S) -HETE also activates PPARα selectively at concentrations as low as 0.3 μM. Stereochemical assignment of the (S) enantiomer is based on comparison of chiral HPLC retention times to published results.

Product Specifications

CAS Number

[98462-03-4]

Product Name Alternative

8 (S) -Hydroxyeicosatetraenoic acid

UNSPSC

12352211

Hazard Statement

H225, H319

Target

PPAR

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/8_S_-HETE.html

Concentration

312.04 μM * 250 μL in Ethanol

Purity

99.9

Smiles

CCCCC/C=C\C/C=C/C=C\[C@H](C/C=C\CCCC(O)=O)O

Molecular Formula

C20H32O3

Molecular Weight

320.47

Precautions

H225, H319

References & Citations

[1]Hughes, et al. Investigation of the mechanism of biosynthesis of 8-hydroxyeicosatetraenoic acid in mouse skin. Biochim. Biophys. Acta 1081 (3), 347-354 (1991) .