HGPRT/TBrHGPRT1-IN-1
HGPRT/TBrHGPRT1-IN-1 (Compound 5) is a selective inhibitor targeting human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) and Trypanosoma bruce HGPRT1 (TBrHGPRT1) (both Ki=3 nM) . HGPRT/TBrHGPRT1-IN-1 ultimately results in decreased cell growth. HGPRT/TBrHGPRT1-IN-1 is primarily used in the research of infectious diseases and cancer[1].
Product Specifications
CAS Number
3081803-13-3
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/hgprt-tbrhgprt1-in-1.html
Solubility
10 mM in DMSO
Smiles
NC1=NC2=C(C(N1)=O)N=CN2[C@@H]3C[C@H](N(C3)C(CCP(O)(O)=O)=O)COCCP(O)(O)=O
Molecular Formula
C15H24N6O9P2
Molecular Weight
494.33
References & Citations
[1]Cheshmazar N, et al. Key structural requirements of benzamide derivatives for histone deacetylase inhibition: design, synthesis and biological evaluation. Future Med Chem. 2024 Apr 16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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