BAY 61-3606 (hydrochloride)
BAY 61-3606 hydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM and an IC50 of 10 nM . BAY 61-3606 hydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BAY 61-3606 hydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates. BAY 61-3606 hydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.
Product Specifications
CAS Number
1615197-10-8
UNSPSC
12352005
Target
Apoptosis; Syk
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bay-61-3606-hydrochloride.html
Purity
98.08
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 160°C)
Smiles
NC(C1=C(N=CC=C1)NC2=NC(C3=CC(OC)=C(C=C3)OC)=CC4=NC=CN24)=O.Cl
Molecular Formula
C20H19ClN6O3
Molecular Weight
426.86
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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