2-Deoxy-D-glucose-13C

2-Deoxy-D-glucose-13C is the 13C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].

Product Specifications

CAS Number

[201612-55-7]

Product Name Alternative

2-DG-13C; 2-Deoxy-D-arabino-hexose-13C; D-Arabino-2-deoxyhexose-13C

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Hexokinase; HSV; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease; Others

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2-deoxy-d-glucose-13c.html

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O=[13CH]C[C@@H](O)[C@H](O)[C@H](O)CO

Molecular Formula

C5 13CH12O5

Molecular Weight

165.15

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Zhu Z, et al. 2-Deoxyglucose as an energy restriction mimetic agent: effects on mammary carcinogenesis and on mammary tumor cell growth in vitro. Cancer Res. 2005 Aug 1;65 (15) :7023-30.; Ueyama A, et al. Nonradioisotope assay of glucose uptake activity in r