SPSB2-iNOS inhibitory cyclic peptide-1
SPSB2-iNOS inhibitory cyclic peptide-1 is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with KD of 4.4 nM. SPSB2-iNOS inhibitory cyclic peptide-1 is resistant to the proteases pepsin, trypsin and α-chymotrypsin. SPSB2-iNOS inhibitory cyclic peptide-1 is stable in human plasma and in oxidative environment[1].
Product Specifications
CAS Number
1621616-13-4
UNSPSC
12352209
Target
NO Synthase
Type
Peptides
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/spsb2-inos-inhibitory-cyclic-peptide-1.html
Purity
99.81
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
Molecular Formula
C35H56N12O14S2
Molecular Weight
933.02
References & Citations
[1]Yap BK, et al., A potent cyclic peptide targeting SPSB2 protein as a potential anti-infective agent. J Med Chem. 2014 Aug 28;57 (16) :7006-15.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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