PROTAC IDO1 Degrader-1

PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to Cereblon E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM) . PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells[1].

Product Specifications

CAS Number

[2488851-89-2]

UNSPSC

12352005

Target

Indoleamine 2,3-Dioxygenase (IDO) ; PROTACs

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/protac-ido1-degrader-1.html

Purity

99.00

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C2=C(NCCOCCOCCOCCOCCOCCOCCOCCNCCNC3=NON=C3/C(NC4=CC(Br)=C(C=C4)F)=N/O)C=CC=C2C(N1C5C(NC(CC5)=O)=O)=O

Molecular Formula

C40H53BrFN9O13

Molecular Weight

966.80

References & Citations

[1]Hu M, et al. Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1. Acta Pharm Sin B. 2020;10 (10) :1943-1953.