Pan-Filovirus GP/Envelope glycoprotein Antibody

RecName: Full=Envelope glycoprotein; AltName: Full=GP1,2; Short=GP; Contains: RecName: Full=Shed GP; AltName: Full=GP1,2-delta; Contains: RecName: Full=GP1; Contains: RecName: Full=GP2; Flags: Precursor, GP, GP1,2, /evidence=ECO:0000255., Filovirus glycoprotein; pfam01611, Envelope glycoprotein. /id=PRO_0000037485., Extracellular. /evidence=ECO:0000255., Shed GP. /id=PRO_0000445686., GP1. /id=PRO_0000037486., /evidence=ECO:0007829|PDB:6HS4., N->D: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829|PDB:6HS4., /evidence=ECO:0007829|PDB:6HS4., Interchain (between GP1 and GP2 chains) . /evidence=ECO:0000269|PubMed:12438572., /evidence=ECO:0007829|PDB:6QD7., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269|PubMed:12438572., Receptor-binding. /evidence=ECO:0000255., D->A: 80% loss of virus capability to enter into host cell., D->E, K: No effect on viral entry., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., L->A: Complete loss of virus capability to enter into host cell., L->F, I, K: 90% loss of virus capability to enter into host cell., /evidence=ECO:0007829|PDB:6HS4., /evidence=ECO:0007829|PDB:6HS4., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., L->A: 90% loss of virus capability to enter into host cell., L->F: Almost complete loss of virus capability to enter into host cell., L->K: Complete loss of virus capability to enter into host cell., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., R->A, E: Complete loss of virus capability to enter into host cell., R->K: No loss of virus capability to enter into host cell., S -> P (in strain: Isolate mouse-adapted) ., /evidence=ECO:0007829|PDB:6HS4., /evidence=ECO:0007829|PDB:6HS4., /evidence=ECO:0007829|PDB:6HS4., F->A, E: Complete loss of virus capability to enter into host cell., F->A: About 50% loss of ability to counteract host BST2. /evidence=ECO:0000269|PubMed:27707924., F->I: No loss of virus capability to enter into host cell., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., K->A, E: 80% loss of virus capability to enter into host cell., K->R: 20% loss of virus capability to enter into host cell., /evidence=ECO:0007829|PDB:6HS4., /evidence=ECO:0007829|PDB:6HS4., /evidence=ECO:0007829|PDB:6HS4., /evidence=ECO:0000255., C->G: Almost complete loss of expression of GP1 and GP2. Almost complete loss of virus capability to enter into host cell. /evidence=ECO:0000269|PubMed:12438572., L->A: About 60% loss of ability to counteract host BST2. /evidence=ECO:0000269|PubMed:27707924., /evidence=ECO:0007829|PDB:9BSV., /evidence=ECO:0007829|PDB:6HS4., /evidence=ECO:0000255., C->G: Reduced levels of expression of GP1 and GP2. 50% loss of virus capability to enter into host cell. /evidence=ECO:0000269|PubMed:12438572., L->A: About 60% loss of ability to counteract host BST2. /evidence=ECO:0000269|PubMed:27707924., /evidence=ECO:0007829|PDB:6HS4., C->S: Almost complete loss of expression of GP1 and GP2. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269|PubMed:12438572., C->S: Reduced levels of expression of GP1 and GP2. Almost complete loss of virus capability to enter into host cell. /evidence=ECO:0000269|PubMed:12438572., /evidence=ECO:0007829|PDB:6HS4., /evidence=ECO:0007829|PDB:6HS4., /evidence=ECO:0007829|PDB:6HS4., I->A: 90% loss of virus capability to enter into host cell., I->E: Complete loss of virus capability to enter into host cell., I->F: 50% loss of virus capability to enter into host cell., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., /evidence=ECO:0007829|PDB:6HS4., /evidence=ECO:0007829|PDB:7JPI., /evidence=ECO:0007829|PDB:7JPI., N->D: No effect on GP1 and GP2 expression. No loss of virus capability to enter into host cell. /evidence=ECO:0000269|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829|PDB:6HS4., /evidence=ECO:0007829|PDB:6HS4., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829|PDB:6HS4., N->Y: No effect on GP1 and GP2 expression. 12% loss of virus capability to enter into host cell. /evidence=ECO:0000269|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829|PDB:6HS4., S -> P (in strain: Isolate mouse-adapted) ., /evidence=ECO:0007829|PDB:6HS4., N->D: No effect on GP1 and GP2 expression. 12% loss of virus capability to enter into host cell. /evidence=ECO:0000269|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829|PDB:6HS4., /evidence=ECO:0007829|PDB:6HS4., /evidence=ECO:0007829|PDB:6HS4., N->D: No effect on GP1 and GP2 expression. 18% loss of virus capability to enter into host cell. /evidence=ECO:0000269|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829|PDB:7TN9., Mucin-like region., /evidence=ECO:0007829|PDB:6HS4., /evidence=ECO:0007829|PDB:7LYD., Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., invasion associated endopeptidase, N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Low complexity. /evidence=ECO:0000256|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., RRTRR->AGTAA: Almost complete loss of cleavage between GP1 and GP2. No loss of infectivity. /evidence=ECO:0000269|PubMed:11152533., RTRR->ATAA: No effect on cleavage between GP1 and GP2. /evidence=ECO:0000269|PubMed:9882347., Cleavage; by host furin. /evidence=ECO:0000269|PubMed:9576958., GP2. /id=PRO_0000037487., /evidence=ECO:0000255., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269|PubMed:12438572., /evidence=ECO:0007829|PDB:6HS4., /evidence=ECO:0007829|PDB:8DPM., Fusion peptide. /evidence=ECO:0000305., /evidence=ECO:0007829|PDB:6HS4., G->R: Reduced infectivity. /evidence=ECO:0000269|PubMed:10482652., L->A, R: Reduced infectivity. /evidence=ECO:0000269|PubMed:10482652., I->A: Reduced infectivity. /evidence=ECO:0000269|PubMed:10482652., I->R: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269|PubMed:10482652., /evidence=ECO:0007829|PDB:6HS4., F->A: Reduced infectivity. /evidence=ECO:0000269|PubMed:10482652., F->R: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269|PubMed:10482652., G->A: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269|PubMed:10482652., P->R: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269|PubMed:10482652., /evidence=ECO:0007829|PDB:6HS4., /evidence=ECO:0007829|PDB:6HS4., I -> T., /evidence=ECO:0007829|PDB:6HS4., /evidence=ECO:0000255., C->S: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269|PubMed:12438572., heptad repeat 1-heptad repeat 2 region of the transmembrane subunit of Filoviridae viruses, Ebola virus and Marburg virus, and related domains; cd09850, homotrimer interface [polypeptide binding], HR1-GP1 interface [polypeptide binding], HR1A, /evidence=ECO:0007829|PDB:2EBO., N->D: Reduced levels of expression of GP, GP1 and GP2. 20% loss of virus capability to enter into host cell. /evidence=ECO:0000269|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., HR1B, HR1C, HR1D, Cl binding site [ion binding], immunosuppressive region, /evidence=ECO:0007829|PDB:2EBO., /evidence=ECO:0007829|PDB:2EBO., /evidence=ECO:0000269|PubMed:12438572., CX (6,7) C motif, C->S: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269|PubMed:12438572., /evidence=ECO:0007829|PDB:2EBO., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269|PubMed:12438572., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269|PubMed:12438572., /evidence=ECO:0000255., /evidence=ECO:0007829|PDB:2EBO., HR2, N->D: Slightly reduced levels of expression of GP1 and GP2. No loss of virus capability to enter into host cell. /evidence=ECO:0000269|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., D->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269|PubMed:15103332., K->R, V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269|PubMed:15103332., T->I: 50% loss of release of soluble GP1,2delta. /evidence=ECO:0000269|PubMed:15103332., L->V: 60% loss of release of soluble GP1,2delta. /evidence=ECO:0000269|PubMed:15103332., L->V: Increased GP shedding. /evidence=ECO:0000269|PubMed:26092855., P->A: 60% loss of release of soluble GP1,2delta., Cleavage; by host ADAM17. /evidence=ECO:0000269|PubMed:15103332., D->E: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269|PubMed:15103332., D->L, V: Increased release of soluble GP1,2delta. /evidence=ECO:0000269|PubMed:15103332., D->V: Decreased GP shedding. /evidence=ECO:0000269|PubMed:26092855., Q->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269|PubMed:15103332., G->V: 40% loss of release of soluble GP1,2delta. /evidence=ECO:0000269|PubMed:15103332., D->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269|PubMed:15103332., N->A: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269|PubMed:15103332., D->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269|PubMed:15103332., N->A: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269|PubMed:15103332., Helical. /evidence=ECO:0000255., Important role for host BST2/tetherin antagonism. /evidence=ECO:0000269|PubMed:27707924., G->L: About 60% loss of viral release; when associated with L-664. /evidence=ECO:0000269|PubMed:29669839., A->L: About 60% loss of viral release; when associated with L-660. /evidence=ECO:0000269|PubMed:29669839., C->A: Reduced palmitoylation. No effect on GP processing and association with retrovirus particle. No loss of virus capability to enter into host cell. Loss of localization to the rafts; when associated with A-670. /evidence=ECO:0000269|PubMed:11152533, ECO:0000269|PubMed:11877482, ECO:0000269|PubMed:12438572., C->F: Slightly reduced levels of expression of GP1 and GP2. Greatly reduced GP processing and association with retrovirus particle. 43% loss of virus capability to enter into host cell. Loss of localization to the rafts; when associated with A-672. /evidence=ECO:0000269|PubMed:11152533, ECO:0000269|PubMed:11877482, ECO:0000269|PubMed:12438572., S-palmitoyl cysteine; by host. /evidence=ECO:0000269|PubMed:11152533., Cytoplasmic. /evidence=ECO:0000255., C->A: Reduced palmitoylation. No effect on GP processing and association with retrovirus particle. No loss of virus capability to enter into host cell. /evidence=ECO:0000269|PubMed:11152533, ECO:0000269|PubMed:12438572., C->F: Slightly reduced levels of expression of GP1 and GP2. Almost no effect on GP processing and association with retrovirus particle. 24% loss of virus capability to enter into host cell. /evidence=ECO:0000269|PubMed:11152533, ECO:0000269|PubMed:12438572., S-palmitoyl cysteine; by host. /evidence=ECO:0000269|PubMed:11152533., Nucleocapsid protein; Protein N, Nucleoprotein. /id=PRO_0000222174., Ebola nucleoprotein; pfam05505, /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite., Acidic residues. /evidence=ECO:0000256|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256|SAM:MobiDB-lite., Acidic residues. /evidence=ECO:0000256|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256|SAM:MobiDB-lite., /evidence=ECO:0007829|PDB:6U55., /evidence=ECO:0007829|PDB:6U52., /evidence=ECO:0007829|PDB:6U52., /evidence=ECO:0007829|PDB:6U52., /evidence=ECO:0007829|PDB:6U52., /evidence=ECO:0007829|PDB:6U52., /evidence=ECO:0007829|PDB:6U52., /evidence=ECO:0007829|PDB:6U55., /evidence=ECO:0007829|PDB:6U55., /evidence=ECO:0007829|PDB:6U55., /evidence=ECO:0007829|PDB:6U55., /evidence=ECO:0007829|PDB:6U52., /evidence=ECO:0007829|PDB:6U52., GP1,2; Virion spike glycoprotein, Filovirus glycoprotein; pfam01611, /evidence=ECO:0000250., Envelope glycoprotein. /evidence=ECO:0000250. /id=PRO_0000314986., Extracellular. /evidence=ECO:0000255., GP1. /evidence=ECO:0000250. /id=PRO_0000314987., Receptor-binding. /evidence=ECO:0000250., /evidence=ECO:0007829|PDB:6BP2., /evidence=ECO:0007829|PDB:6BP2., /evidence=ECO:0007829|PDB:6BP2., /evidence=ECO:0007829|PDB:6BP2., /evidence=ECO:0007829|PDB:6BP2., /evidence=ECO:0007829|PDB:6BP2., /evidence=ECO:0007829|PDB:6BP2., /evidence=ECO:0007829|PDB:6BP2., /evidence=ECO:0007829|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829|PDB:6BP2., /evidence=ECO:0007829|PDB:6BP2., /evidence=ECO:0007829|PDB:6BP2., /evidence=ECO:0007829|PDB:6BP2., /evidence=ECO:0007829|PDB:6BP2., /evidence=ECO:0007829|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Polar residues. /evidence=ECO:0000256|SAM:MobiDB-lite., Mucin-like region. /evidence=ECO:0000250., Polar residues. /evidence=ECO:0000256|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Low complexity. /evidence=ECO:0000256|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Polar residues. /evidence=ECO:0000256|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Polar residues. /evidence=ECO:0000256|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Low complexity. /evidence=ECO:0000256|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Cleavage; by host furin. /evidence=ECO:0000250., GP2. /evidence=ECO:0000250. /id=PRO_0000314988., /evidence=ECO:0007829|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829|PDB:6BP2., /evidence=ECO:0007829|PDB:6BP2., /evidence=ECO:0007829|PDB:6BP2., Fusion peptide. /evidence=ECO:0000250., /evidence=ECO:0007829|PDB:6BP2., /evidence=ECO:0007829|PDB:6BP2., /evidence=ECO:0007829|PDB:6BP2., /evidence=ECO:0007829|PDB:6BP2., /evidence=ECO:0007829|PDB:6BP2., heptad repeat 1-heptad repeat 2 region of the transmembrane subunit of Filoviridae viruses, Ebola virus and Marburg virus, and related domains; cd09850, homotrimer interface [polypeptide binding], HR1-GP1 interface [polypeptide binding], HR1A, N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., HR1B, HR1C, HR1D, Cl binding site [ion binding], immunosuppressive region, /evidence=ECO:0007829|PDB:6BP2., CX (6,7) C motif, /evidence=ECO:0007829|PDB:6BP2., HR2, N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Helical. /evidence=ECO:0000255., Cytoplasmic. /evidence=ECO:0000255., S-palmitoyl cysteine; by host. /evidence=ECO:0000250|UniProtKB:P35253., S-palmitoyl cysteine; by host. /evidence=ECO:0000250|UniProtKB:P35253.