(S) -Navlimetostat
(S) -Navlimetostat (example 16-7) is the S-enantiomer of Navlimetostat. (S) -Navlimetostat is a PRMT5/MTA complex inhibitor, with an IC50 of 7070 nM[1].
Product Specifications
CAS Number
2630904-44-6
Product Name Alternative
(S) -MRTX-1719; (S) -BMS-986504
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-mrtx-1719.html
Purity
95.15
Solubility
10 mM in DMSO
Smiles
FC1=C(C=C(C(C#N)=[C@@]1[C@@]2=C(C3=CC=C4C(C(CN)=NNC4=O)=C3)C=NN2C)OC5CC5)Cl
Molecular Formula
C23H18ClFN6O2
Molecular Weight
464.88
References & Citations
[1]Thomas P. BOBINSKI, et al. Mta-cooperative prmt5 inhibitors. WO2021050915A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT5
Available Sizes
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