Protein kinase inhibitor 1 (hydrochloride)

Protein kinase inhibitor 1 hydrochloride is a potent HIPK2 inhibitor, with IC50s of 136 and 74 nM for HIPK1 and HIPK2, and a Kd of 9.5 nM for HIPK2.

Product Specifications

CAS Number

[2321337-71-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DYRK

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protein-kinase-inhibitor-1-hydrochloride.html

Purity

98.0

Solubility

DMSO : 8.33 mg/mL (ultrasonic) |H2O : 9.09 mg/mL (ultrasonic)

Smiles

O=C(NC/1=O)SC1=C\C2=CNC(C(C3=CC=C(N4CCNCC4)N=C3)=C2)=O.[H]Cl

Molecular Formula

C18H18ClN5O3S

Molecular Weight

419.89

Precautions

H302, H315, H319, H335

References & Citations

[1]Miduturu CV, et al. High-throughput kinase profiling: a more efficient approach toward the discovery of new kinaseinhibitors. Chem Biol. 2011 Jul 29;18 (7) :868-79.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

DYRK1; DYRK2

Citation 01

Biol Direct. 2025 Jun 19;20 (1) :71.|EBioMedicine. 2021 Dec:74:103713.|EBioMedicine. 2022 Nov:85:104274.|J Biochem Mol Toxicol. 2021 May;35 (5) :e22737.