Protein kinase inhibitor 1 (hydrochloride)
Protein kinase inhibitor 1 hydrochloride is a potent HIPK2 inhibitor, with IC50s of 136 and 74 nM for HIPK1 and HIPK2, and a Kd of 9.5 nM for HIPK2.
Product Specifications
CAS Number
2321337-71-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DYRK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protein-kinase-inhibitor-1-hydrochloride.html
Purity
98.0
Solubility
DMSO : 8.33 mg/mL (ultrasonic) |H2O : 9.09 mg/mL (ultrasonic)
Smiles
O=C(NC/1=O)SC1=C\C2=CNC(C(C3=CC=C(N4CCNCC4)N=C3)=C2)=O.[H]Cl
Molecular Formula
C18H18ClN5O3S
Molecular Weight
419.89
Precautions
H302, H315, H319, H335
References & Citations
[1]Miduturu CV, et al. High-throughput kinase profiling: a more efficient approach toward the discovery of new kinaseinhibitors. Chem Biol. 2011 Jul 29;18 (7) :868-79.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DYRK1; DYRK2
Citation 01
Biol Direct. 2025 Jun 19;20 (1) :71.|EBioMedicine. 2021 Dec:74:103713.|EBioMedicine. 2022 Nov:85:104274.|J Biochem Mol Toxicol. 2021 May;35 (5) :e22737.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC680391-100 1x 100 µL
CD81 / TAPA-1 (1.3.3.22), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
