Tyrphostin AG30
Tyrphostin AG30 (AG30) is a potent and selective EGFR tyrosine kinase inhibitor. Tyrphostin AG30 (AG30) selectively inhibits self renewal induction by c-ErbB, and is able to inhibit activation of STAT5 by c-ErbB in primary erythroblasts[1][2].
Product Specifications
CAS Number
122520-79-0
Product Name Alternative
AG30
UNSPSC
12352005
Hazard Statement
H302+H312+H332, H315, H319
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tyrphostin-ag30.html
Concentration
10mM
Purity
99.70
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(/C(C#N)=C/C1=CC=C(C(O)=C1)O)O
Molecular Formula
C10H7NO4
Molecular Weight
205.17
Precautions
H302+H312+H332, H315, H319
References & Citations
[1]Volberg T, et al. The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions. EMBO J. 1992 May;11 (5) :1733-42.|[2]Wessely O, et al. Distinct roles of the receptor tyrosine kinases c-ErbB and c-Kit in regulating the balance between erythroid cell proliferation and differentiation. Cell Growth Differ. 1997 May;8 (5) :481-93.|[3]Banerjee S, et al. Epidermal growth factor induces WISP-2/CCN5 expression in estrogen receptor-alpha-positive breast tumor cells through multiple molecular cross-talks. Mol Cancer Res. 2005 Mar;3 (3) :151-62.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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