FAAH inhibitor 1

FAAH inhibitor 1 (Benzothiazole analog 3) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 18±8 nM[1].

Product Specifications

CAS Number

[326866-17-5]

Product Name Alternative

Benzothiazole analog 3

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Autophagy; FAAH

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/faah-inhibitor-1.html

Purity

98.30

Solubility

DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1=CC=C(N=C(C2=CC=C(NC(C3CCN(S(=O)(C4=CC=CS4)=O)CC3)=O)C=C2)S5)C5=C1

Molecular Formula

C24H23N3O3S3

Molecular Weight

497.65

Precautions

H302, H315, H319

References & Citations

[1]Wang, Xueqing; Sarris, Katerina; Kage, Karen; et al. Synthesis and Evaluation of Benzothiazole-Based Analogues as Novel, Potent, and Selective Fatty Acid Amide Hydrolase Inhibitors. Journal of Medicinal Chemistry (2009), 52 (1), 170-180.|[2]Meyers, Marvin J.; Long, Scott A.; Pelc, Matthew J.; et al. Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH) . Part 1: Identification of 7-azaspiro[3.5]nonane and 1-oxa-8-azaspiro[4.5]decane as lead scaffolds. Bioorganic & Medicinal Chemistry Letters (2011), 21 (21), 6538-6544.