Luotonin F
Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge. Luotonin F shows cytotoxic activity against mouse leukemia P-388 cells by inhibiting human topoisomerase II[1][2].
Product Specifications
CAS Number
244616-85-1
UNSPSC
12352005
Target
Topoisomerase
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/luotonin-f.html
Solubility
10 mM in DMSO
Smiles
O=C1NC(C(C2=CC3=C(N=C2)C=CC=C3)=O)=NC4=CC=CC=C41
Molecular Formula
C18H11N3O2
Molecular Weight
301.30
References & Citations
[1]Liang JL, et al. Recent advances in the studies on luotonins. Molecules. 2011 Jun 14;16 (6) :4861-83.|[2]Ma Z, et al. Novel quinazoline-quinoline alkaloids with cytotoxic and DNA topoisomerase II inhibitory activities. Bioorg Med Chem Lett. 2004 Mar 8;14 (5) :1193-6.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Topo II
Available Sizes
Frequently Asked Questions
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