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Luotonin F

Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge. Luotonin F shows cytotoxic activity against mouse leukemia P-388 cells by inhibiting human topoisomerase II[1][2].

Product Specifications

CAS Number

244616-85-1

UNSPSC

12352005

Target

Topoisomerase

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/luotonin-f.html

Solubility

10 mM in DMSO

Smiles

O=C1NC(C(C2=CC3=C(N=C2)C=CC=C3)=O)=NC4=CC=CC=C41

Molecular Formula

C18H11N3O2

Molecular Weight

301.30

References & Citations

[1]Liang JL, et al. Recent advances in the studies on luotonins. Molecules. 2011 Jun 14;16 (6) :4861-83.|[2]Ma Z, et al. Novel quinazoline-quinoline alkaloids with cytotoxic and DNA topoisomerase II inhibitory activities. Bioorg Med Chem Lett. 2004 Mar 8;14 (5) :1193-6.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Topo II

Available Sizes

Frequently Asked Questions

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