ERK2/p38α MAPK-IN-1
ERK2/p38α MAPK-IN-1 (Compound 1, In silico Hit-2) is a potent and selective ERK2 and p38α MAPK inhibitor, with an IC50 of 82 μM for ERK2. ERK2/p38α MAPK-IN-1 binds to the allosteric site of ERK2 and p38α MAPK in distinct manners. ERK2/p38α MAPK-IN-1 can be used for the research of type 2 diabetes[1].
Product Specifications
CAS Number
1016427-72-7
UNSPSC
12352005
Target
ERK; p38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/erk2-p38α-mapk-in-1.html
Solubility
10 mM in DMSO
Smiles
COC1=C(OC)C=C(N=C(NC(C2=CSC(COC3=CC=C(F)C=C3)=N2)=O)S4)C4=C1
Molecular Formula
C20H16FN3O4S2
Molecular Weight
445.49
References & Citations
[1]Hasegawa S, et al. Distinct binding modes of a benzothiazole derivative confer structural bases for increasing ERK2 or p38α MAPK selectivity. Biochem Biophys Res Commun. 2024 Apr 16;704:149707.|[2]Kinoshita T, et al. Identification of allosteric ERK2 inhibitors through in silico biased screening and competitive binding assay. Bioorg Med Chem Lett. 2016 Feb 1;26 (3) :955-958.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
245968-ML750 100 µL
FANCG (Fanconi Anemia, Complementation Group G, FAG, XRCC9) (MaxLight 750) discontinued
Sign In for Pricing
View Details 
GTR10329596 96 Well
Guinea Pig Olfactory receptor 2D2 (OR2D2) ELISA Kit
Sign In for Pricing
View Details MBS6157657-01 0.1 mL
EphA3 (Ephrin Type-A Receptor 3, Tyrosine-protein Kinase Receptor ETK1, HEK, EPH-like Kinase 4, HEK4, EK4, Tyrosine-protein Kinase TYRO4, ETK, ETK1, HEK, TYRO4) (PE)
Sign In for Pricing
View Details