DB772 (hydrate)

DB772 hydrate is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 also has anti-prion activity[1].

Product Specifications

Product Name Alternative

PF-06651600 (tosylate)

UNSPSC

12352005

Target

Flavivirus

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/db772-hydrate.html

Purity

99.89

Solubility

DMSO : ≥ 4 mg/mL

Smiles

[H]Cl.C1(C2=CC=C(C3=CC=C(C4=NCCN4)C=C3)O2)=NC5=CC=CC=C5N1.[2.8].[4].O

Molecular Formula

C20H16N4O.2.8HCl.4H2O

Molecular Weight

502.54

References & Citations

[1]James B Stanton, et al. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PLoS One. 2012;7 (11) :e51173.|[2]Benjamin W Newcomer, et al. Efficacy of an antiviral compound to inhibit replication of multiple pestivirus species. Antiviral Res. 2012 Nov;96 (2) :127-9.|[3]Kelcey D Dinkel, et al. Antiprion Activity of DB772 and Related Monothiophene- and Furan-Based Analogs in a Persistently Infected Ovine Microglia Culture System. Antimicrob Agents Chemother. 2016 Aug 22;60 (9) :5467-82.