Apoptosis, Caspase Antibody
IGN523 is an anti-CD98 antibody (hCD98, KD = 0.55 nM) that induces antibody-dependent cell-mediated cytotoxicity (ADCC) . It permeabilizes lysosomal membranes and inhibits essential amino acid transport function, leading to caspase-3 and caspase-7 mediated apoptosis of tumor cells. IGN523 inhibits tumor growth in various tumor xenograft models and can be used for research on cancers such as non-small cell lung cancer (NSCLC) and acute myeloid leukemia (AML) .
Product Specifications
Target
Apoptosis, Caspase
Conjugation
Unconjugated
Field of Research
Cell Biology, Protein Biochemistry
Concentration
7.68 mg/mL
Purity
95.00% (May vary between batches)
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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