IGluR Antibody
ART5803 is a humanized IgG1 monoclonal antibody inhibitor targeting NMDAR. It binds with high affinity to the N-terminal domain (NTD) of the NMDAR GluN1 subunit (GluN1-NTD) . ART5803 blocks the internalization of NMDAR induced by pathogenic autoantibodies and restores the expression and function of NMDAR on the cell surface. Moreover, ART5803 reverses behavioral abnormalities and the expression of NMDAR in marmoset disease models. ABT-147 can be utilized in research on anti-NMDAR encephalitis.
Product Specifications
Target
IGluR
Clonality
Monoclonal
Conjugation
Unconjugated
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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