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NF-κB, TNF, c-Myc Antibody

VTX-0811 is a human IgG4 monoclonal antibody (mAb) that targets PSGL1/CD162. It modulates immune signaling pathways by enhancing TNF-α/NF-κB and chemokine-mediated signaling while reducing oxidative phosphorylation, fatty acid metabolism, and Myc signaling. VTX-0811 increases the proportion of CD8+ T cells among infiltrating T cells and exhibits antitumor activity in humanized mouse PDX models of melanoma.

Product Specifications

Target

NF-κB, TNF, c-Myc

Clonality

Monoclonal

Conjugation

Unconjugated

Field of Research

Cancer Biology; Immunology & Inflammation, Cell Biology, Signal Transduction

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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