Berninamycin A

Berninamycin A is a cyclic thiopeptide antibiotic first isolated from S. bernensis. It inhibits protein biosynthesis in Gram positive bacteria through binding with ribosomal subunits. Cyclic thiopeptide antibiotics, including berninamycin A, induce the transcriptional activator TipA in Streptomyces.

Product Specifications

CAS Number

[58798-97-3]

UNSPSC

12352209

Target

Antibiotic; Bacterial

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/berninamycin-a.html

Smiles

O=C(C1=NC(C2=COC3=N2)=C(C4=NC(C(N[C@]([C@H](O)C)([H])C(N/C(C5=NC(C(NC(C(N[C@@H](C(C)(O)C)C(NC(C6=NC(C(NC(C(NC3=C)=O)=C)=O)=C(C)O6)=C)=O)=O)=C)=O)=C(C)O5)=C\C)=O)=O)=CS4)C=C1)NC(C(NC(C(N)=O)=C)=O)=C

Molecular Formula

C51H51N15O15S

Molecular Weight

1146.11

References & Citations

[1]Chiu, et al. Broad spectrum thiopeptide recognition specificity of the Streptomyces lividans TipAL protein and its role in regulating gene expression. J. Biol. Chem. 274 (29), 20578-20586 (1999) .