Berninamycin A
Berninamycin A is a cyclic thiopeptide antibiotic first isolated from S. bernensis. It inhibits protein biosynthesis in Gram positive bacteria through binding with ribosomal subunits. Cyclic thiopeptide antibiotics, including berninamycin A, induce the transcriptional activator TipA in Streptomyces.
Product Specifications
CAS Number
58798-97-3
UNSPSC
12352209
Target
Antibiotic; Bacterial
Type
Peptides
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/berninamycin-a.html
Smiles
O=C(C1=NC(C2=COC3=N2)=C(C4=NC(C(N[C@]([C@H](O)C)([H])C(N/C(C5=NC(C(NC(C(N[C@@H](C(C)(O)C)C(NC(C6=NC(C(NC(C(NC3=C)=O)=C)=O)=C(C)O6)=C)=O)=O)=C)=O)=C(C)O5)=C\C)=O)=O)=CS4)C=C1)NC(C(NC(C(N)=O)=C)=O)=C
Molecular Formula
C51H51N15O15S
Molecular Weight
1146.11
References & Citations
[1]Chiu, et al. Broad spectrum thiopeptide recognition specificity of the Streptomyces lividans TipAL protein and its role in regulating gene expression. J. Biol. Chem. 274 (29), 20578-20586 (1999) .
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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