EGFR Antibody
MM-111 is a bispecific antibody fusion protein targeting the oncogenic units ErbB2/ErbB3. It obstructs the activation of the PI3K survival pathway. By binding to the ErbB2 receptor, MM-111 localizes the bispecific molecule to ErbB2-overexpressing tumor cells, facilitating the interaction of its anti-ErbB3 arm with the ErbB3 receptor. This binding inhibites ErbB3 signaling by preventing the ErbB3 receptor from associating with its physiological ligand, heregulin. MM-111 is applicable in the study of ErbB2-overexpressing breast tumors.
Product Specifications
Target
EGFR
Clonality
Recombinant
Conjugation
Unconjugated
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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