DS55980254
DS55980254 is the orally active inhibitor for phosphatidylserine synthase 1 (PTDSS1) that blocks the synthesis of intracellular phosphatidylserine. PTDSS1 deficiency affects the balance of cell membrane phospholipid components, and activates B cell receptor (BCR) signaling pathway[1][2].
Product Specifications
CAS Number
2488609-43-2
UNSPSC
12352005
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ds55980254.html
Purity
99.65
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
FC(C)(CN1[C@](C2=CC=C(OC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C=C2)([H])C4=C(C5=CC=CC(N6)=C5OC6=O)NN=C4C1=O)F
Molecular Formula
C29H18F8N4O4
Molecular Weight
638.46
References & Citations
[1]Keisuke Suzuki, et al. Efficient Multikilogram-Scale Synthesis of PTDSS1 Inhibitor: Development of a Practical and Scalable Optical Resolution Method for Chiral 2,3-Pyrrolidinedione. Org. Process Res. Dev. 2024.|[2]Omi J, et al., Phosphatidylserine synthesis controls oncogenic B cell receptor signaling in B cell lymphoma. J Cell Biol. 2024 Feb 5;223 (2) :e202212074.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LC424660 20 µg
Renin (REN) (NM_000537) Human Over-expression Lysate
Sign In for Pricing
View Details 
TA423815 100 µL
Activin A Receptor Type IB (ACVR1B) Rabbit Monoclonal Antibody
Sign In for Pricing
View Details 