DS55980254

DS55980254 is the orally active inhibitor for phosphatidylserine synthase 1 (PTDSS1) that blocks the synthesis of intracellular phosphatidylserine. PTDSS1 deficiency affects the balance of cell membrane phospholipid components, and activates B cell receptor (BCR) signaling pathway[1][2].

Product Specifications

CAS Number

[2488609-43-2]

UNSPSC

12352005

Target

Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ds55980254.html

Purity

99.65

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

FC(C)(CN1[C@](C2=CC=C(OC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C=C2)([H])C4=C(C5=CC=CC(N6)=C5OC6=O)NN=C4C1=O)F

Molecular Formula

C29H18F8N4O4

Molecular Weight

638.46

References & Citations

[1]Keisuke Suzuki, et al. Efficient Multikilogram-Scale Synthesis of PTDSS1 Inhibitor: Development of a Practical and Scalable Optical Resolution Method for Chiral 2,3-Pyrrolidinedione. Org. Process Res. Dev. 2024.|[2]Omi J, et al., Phosphatidylserine synthesis controls oncogenic B cell receptor signaling in B cell lymphoma. J Cell Biol. 2024 Feb 5;223 (2) :e202212074.