Moringin

Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC50 of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities[1][2].

Product Specifications

CAS Number

[73255-40-0]

UNSPSC

12352005

Hazard Statement

H317, H334

Target

TRP Channel

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/moringin.html

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@H]([C@@H]([C@H]1O)O)[C@@H](O[C@H]1C)OC(C=C2)=CC=C2CN=C=S

Molecular Formula

C14H17NO5S

Molecular Weight

311.35

Precautions

H317, H334

References & Citations

[1]Gigliola Borgonovo, et al. Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro. Molecules. 2020 Feb 22;25 (4) :976.|[2]Santa Cirmi, et al. Moringin from Moringa Oleifera Seeds Inhibits Growth, Arrests Cell-Cycle, and Induces Apoptosis of SH-SY5Y Human Neuroblastoma Cells through the Modulation of NF-κB and Apoptotic Related Factors. Int J Mol Sci. 2019 Apr 19;20 (8) :1930.|[3]Sabrina Giacoppo, et al. Moringin activates Wnt canonical pathway by inhibiting GSK3β in a mouse model of experimental autoimmune encephalomyelitis. Drug Des Devel Ther. 2016 Oct 4;10:3291-3304.