Acid Red 94 (sodium)

Acid Red 94 sodium, a synthetic fluorescein derivative, is a deep red dye primarily composed of 4,5,6,7-tetrachloro-2,4,5,7-tetraiodo fluorescein. It is widely used as an ophthalmic diagnostic agent to detect dry or damaged cells on the ocular surface. Acid Red 94 sodium exhibits antitumor activity and can inhibit Friend Leukemia Virus (FLV) infection through photodynamic action. Additionally, Acid Red 94 sodium can inhibit Aβ aggregation through light irradiation. Acid Red 94 sodium holds potential for use in cancer, viral infections, and neurodegenerative disease research[1][2][3][4][5][6].

Product Specifications

CAS Number

[632-69-9]

UNSPSC

12171500

Hazard Statement

H302, H315, H319, H335

Target

Amyloid-β; Influenza Virus; Photosensitizer

Type

Dye Reagents

Related Pathways

Anti-infection; Apoptosis; Neuronal Signaling

Field of Research

Cancer; Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rose-bengal-sodium.html

Purity

99.90

Solubility

H2O : 31.25 mg/mL (ultrasonic)

Smiles

O=C1OC2(C3=C(OC4=C2C=C(I)C(O[Na])=C4I)C(I)=C(O[Na])C(I)=C3)C5=C1C(Cl)=C(Cl)C(Cl)=C5Cl

Molecular Formula

C20H2Cl4I4Na2O5

Molecular Weight

1017.64

Precautions

H302, H315, H319, H335

References & Citations

[1]Doughty MJ, et, al. Fluorescence characteristics of sodium fluorescein-rose bengal ophthalmic solution mixtures. Cont Lens Anterior Eye. 2014 Oct; 37 (5) : 358-62.|[2]Roat MI, et, al. The antiviral effects of rose bengal and fluorescein. Arch Ophthalmol. 1987 Oct; 105 (10) : 1415-7.|[3]Mousavi SH, et al. Direct toxicity of Rose Bengal in MCF-7 cell line: role of apoptosis. Food Chem Toxicol. 2009 Apr;47 (4) :855-9.|[4]Lee JS, et al. Photo-induced inhibition of Alzheimer's β-amyloid aggregation in vitro by rose bengal. Biomaterials. 2015 Jan;38:43-9.|[5]Toomey P, et al. Intralesional injection of rose bengal induces a systemic tumor-specific immune response in murine models of melanoma and breast cancer. PLoS One. 2013 Jul 17;8 (7) :e68561.|[6]Stevenson NR, Lenard J. Antiretroviral activities of hypericin and rose bengal: photodynamic effects on Friend leukemia virus infection of mice. Antiviral Res. 1993 Jun;21 (2) :119-27.