FMK
FMK is a an irreversible RSK2 kinase inhibitor, that covalently modifies the C-terminal kinase domain of RSK.
Product Specifications
CAS Number
821794-92-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ribosomal S6 Kinase (RSK)
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/FMK.html
Concentration
10mM
Purity
99.83
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
FCC(C1=C(C2=C(N=CN=C2N1CCCO)N)C3=CC=C(C=C3)C)=O
Molecular Formula
C18H19FN4O2
Molecular Weight
342.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Cuello F, et al. 
 Evidence for direct regulation of myocardial Na+/H+ exchanger isoform 1 phosphorylation and activity by 90-kDa ribosomal S6 kinase (RSK) : effects of the novel and specific RSK inhibitor fmk on responses to alpha1-adrenergic stimulation.|[2]Bain J, et al. 
 The selectivity of protein kinase inhibitors: a further update.
 Biochem J. 2007 Dec 15;408 (3) :297-315.|[3]Kang S, et al. FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway. Cancer Cell. 2007 Sep;12 (3) :187-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RSK2
Available Sizes
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