Zastaprazan

Zastaprazan (JP-1366) is a proton pump inhibitor and a potent potassium-competitive acid blocker. Zastaprazan can be used in the research of gastrointestinal inflammatory diseases or gastric acid-related diseases such as gastroesophageal reflux disease[1][2].

Product Specifications

CAS Number

[2133852-18-1]

Product Name Alternative

JP-1366

UNSPSC

12352005

Target

Proton Pump

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/zastaprazan.html

Concentration

10mM

Purity

99.96

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C(N1CCC1)C2=CN3C(C)=C(C)N=C3C(NCC4=C(C)C=CC=C4C)=C2

Molecular Formula

C22H26N4O

Molecular Weight

362.47

References & Citations

[1]Jeongmin Kim, et al. Imidazo[1,2-a]pyridine derivatives, methods for preparing the same and use thereof. WO2018008929A1. 2018-01-11.|[2]Oh JH, et al. Randomized, Double-Blind, Active-Controlled Phase 3 Study to Evaluate Efficacy and Safety of Zastaprazan Compared With Esomeprazole in Erosive Esophagitis. Am J Gastroenterol. 2025 Feb 1;120 (2) :353-361.