PF-06928215
PF-06928215 is a cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC50 of 4.9 μΜ. PF-06928215 has a high binding affinity of 0.2 μM (Kd) [1].
Product Specifications
CAS Number
[2378173-15-8]
Product Name Alternative
BafA1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cyclic GMP-AMP Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/PF-06928215.html
Concentration
10mM
Purity
99.68
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
OC1=CC(C2=CC=CC=C2)=NC3=C(C(N[C@H]4CCCC[C@H]4C(O)=O)=O)C=NN13
Molecular Formula
C20H20N4O4
Molecular Weight
380.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Hall J, et al. Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS One. 2017 Sep 21;12 (9) :e0184843.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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