Biotin-PEGn-NHS ester

Biotin-PEGn-NHS ester is a biotin-labeled PROTAC linker, which belongs to the PEG class and can be used to synthesize PROTAC molecules. Biotin-PEGn-NHS ester can interact with free neutral avidin in solution and successfully target malignant glioma cells. Biotin-PEGn-NHS ester can also be grafted onto the amino group of GelMA to prepare biotin-modified functionalized hydrogel, gelatin methacryloyl (Bio-GelMA) [1][2].

Product Specifications

CAS Number

[365441-71-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Liposome; PROTAC Linkers

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/biotin-pegn-nhs-ester.html

Purity

98.0

Smiles

O=C1NC2CSC(C2N1)CCCCC(NCCOCCOCCC(ON3C(CCC3=O)=O)=O)=O.[n]

Molecular Formula

(C2H4O) nC19H28N4O7S

Precautions

H302, H315, H319, H335

References & Citations

[1]Maldiney T, et al. In vitro targeting of avidin-expressing glioma cells with biotinylated persistent luminescence nanoparticles. Bioconjug Chem. 2012 Mar 21;23 (3) :472-8.|[2]Deng D, et al. Biotin-Avidin System-Based Delivery Enhances the Therapeutic Performance of MSC-Derived Exosomes. ACS Nano. 2023 May 9;17 (9) :8530-8550.