PCSK9, Rhesus Macaque (HEK293, His)

PCSK9 protein regulates cholesterol levels by degrading LDLR, VLDLR, LRP1/APOER and LRP8/APOER2 receptors. It promotes LDLR degradation through non-proteolytic mechanisms, disrupts LDLR recycling, induces LDLR ubiquitination, and inhibits APOB degradation. PCSK9 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived PCSK9 protein, expressed by HEK293 , with C-His labeled tag. The total length of PCSK9 Protein, Rhesus Macaque (HEK293, His) is 662 a.a., with molecular weight of ~20 & 62 kDa, respectively.

QEDEDGDYEE LVLALRSEED GLADAPEHGA TATFHRCAKD PWRLPGTYVV VLKEETHRSQ SERTARRLQA QAARRGYLTK ILHVFHHLLP GFLVKMSGDL LELALKLPHV DYIEEDSSVF AQSIPWNLER ITPARYRADE YQPPKGGSLV EVYLLDTSIQ SDHREIEGRV MVTDFESVPE EDGTRFHRQA SKCDSHGTHL AGVVSGRDAG VAKGAGLRSL RVLNCQGKGT VSGTLIGLEF IRKSQLVQPV GPLVVLLPLA GGYSRVFNAA CQRLARAGVV LVTAAGNFRD DACLYSPASA PEVITVGATN AQDQPVTLGT LGTNFGRCVD LFAPGEDIIG ASSDCSTCFV SRSGTSQAAA HVAGIAAMML SAEPELTLAE LRQRLIHFSA KDVINEAWFP EDQRVLTPNL VAALPPSTHR AGWQLFCRTV WSAHSGPTRM ATAVARCAQD EELLSCSSFS RSGKRRGERI EAQGGKRVCR AHNAFGGEGV YAIARCCLLP QVNCSVHTAP PAGASMGTRV HCHQQGHVLT GCSSHWEVED LGTHKPPVLR PRGQPNQCVG HREASIHASC CHAPGLECKV KEHGIPAPQE QVIVACEDGW TLTGCSPLPG TSHVLGAYAV DNTCVVRSRD VSTTGSTSKE AVAAVAICCR SRHLVQASQE LQ