TNF, Apoptosis Antibody
XmAb5485 is a humanized anti-CD40 monoclonal antibody engineered with an Fc domain modification, exhibiting high affinity for Fc-γ receptors. It effectively induces antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) against tumor cells. Additionally, XmAb5485 suppresses tumor cell proliferation and triggers apoptosis. This compound demonstrates pronounced cytotoxicity against lymphoma, leukemia, multiple myeloma cell lines, and primary cancer cells.
Product Specifications
Target
TNF, Apoptosis
Clonality
Monoclonal
Conjugation
Unconjugated
Field of Research
Cell Biology, Immunology & Inflammation; Cell Biology
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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