Stacofylline

Stacofylline (S 9977 free base; S 9977-2 free base), a Xanthine (HY-W017389) derivative, is a potent AChE inhibitor with an IC50 of 5-50 nM. Stacofylline shows anti-amnesic and promnesic activities[1][2].

Product Specifications

CAS Number

[98833-92-2]

Product Name Alternative

S 9977 (free base) ; S 9977-2 (free base)

UNSPSC

12352005

Target

Cholinesterase (ChE) ; Drug Derivative

Type

Reference compound

Related Pathways

Neuronal Signaling; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/stacofylline.html

Solubility

10 mM in DMSO

Smiles

CN1C2=C(N(C(N(C)C2=O)=O)C)N=C1CCCN3CCN(C(N(CC)CC)=O)CC3

Molecular Formula

C20H33N7O3

Molecular Weight

419.52

References & Citations

[1]Roger D. Porsolt, et al. Potential cognition-enhancing properties of S 9977 in three moenls of amnesia in the mouse. Drug Development Research. 1992.|[2]L E Trudeau, et al. Xanthine derivatives IBMX and S-9977-2 potentiate transmission at an Aplysia central cholinergic synapse. Brain Res. 1992 Jul 17;586 (1) :78-85.