2-Hydroxy-3-methylbutanoic acid

2-Hydroxy-3-methylbutanoic acid is an α-hydroxy analogue of valine and a valine precursor that reduces urea excretion. 2-Hydroxy-3-methylbutanoic acid can promote the growth of chickens and rats, and is converted into valine in the body, participating in protein synthesis and maintaining nitrogen balance, thereby supporting animal growth and development. 2-Hydroxy-3-methylbutanoic acid has a more significant effect on the valine-deficient dietary model. 2-Hydroxy-3-methylbutanoic acid is mainly used in animal nutrition research to evaluate its potential application as a nitrogen source substitute in feed[1][2][3].

Product Specifications

CAS Number

[4026-18-0]

Product Name Alternative

α-Hydroxyisovaleric acid

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/2-Hydroxy-3-methylbutanoic_acid.html

Concentration

10mM

Purity

98.57

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C)C(O)C(O)=O

Molecular Formula

C5H10O3

Molecular Weight

118.13

Precautions

H315, H319, H335

References & Citations

[1]Pan YM, et al. Improved procedure for the analysis of gamma-hydroxybutyrate and ethylene glycol in whole blood. J Anal Toxicol. 2001 Jul-Aug;25 (5) :328-32.|[2]Boebel KP, et al. Comparative utilization of the alpha-keto and D- and L-alpha-hydroxy analogs of leucine, isoleucine and valine by chicks and rats. J Nutr. 1982 Oct;112 (10) :1929-39.|[3]Therapeutic compositions comprising alpha-hydroxy analogs of essential amino acids and their administration to humans for promotion of protein synthesis and suppression of urea formation. United States, US4100160 A 1978-07-11.