CYP19A1-IN-2

CYP19A1-IN-2 (Compound 13h) is a nonsteroidal aromatase (CYP19A1) inhibitor (IC50=0.09 nM) . CYP19A1-IN-2 has potential for breast cancer research[1]. CYP19A1-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[3033282-93-5]

UNSPSC

12352005

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nonsteroidal-aromatase-inhibitor-1.html

Purity

98.88

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CC#CCOC1=CC=C2C=C(OC2=C1)C(C3=CC=C(C=C3)C#N)N4N=CN=C4

Molecular Formula

C22H16N4O2

Molecular Weight

368.39

References & Citations

[1]Ahmed G Eissa, et al. 4th generation nonsteroidal aromatase inhibitors: An iterative SAR-guided design, synthesis, and biological evaluation towards picomolar dual binding inhibitors. Eur J Med Chem. 2022 Jul 6;240:114569.