APN-PEG5-VC-PAB-MMAE

APN-PEG5-VC-PAB-MMAE is a drug-linker conjugate part of INA03 (a transferrin-competitive antibody-drug conjugate against CD71) [1].

Product Specifications

CAS Number

[2252392-31-5]

UNSPSC

12352005

Target

Drug-Linker Conjugates for ADC

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/apn-peg5-vc-pab-mmae.html

Purity

95.19

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@@H](NC([C@@H](NC(CCOCCOCCOCCOCCOCC(N=N4)=CN4C5=CC=C(C#CC#N)C=C5)=O)C(C)C)=O)CCCNC(N)=O)=O)=O)=O)=O)=O)OC)=O

Molecular Formula

C81H120N14O18

Molecular Weight

1577.90

References & Citations

[1]Bratti M, et al. INA03, a potent transferrin-competitive antibody-drug conjugate against CD71, for a safer acute leukemia treatment. Mol Cancer Ther. 2024 Apr 20.