APN-PEG5-VC-PAB-MMAE
APN-PEG5-VC-PAB-MMAE is a drug-linker conjugate part of INA03 (a transferrin-competitive antibody-drug conjugate against CD71) [1].
Product Specifications
CAS Number
2252392-31-5
UNSPSC
12352005
Target
Drug-Linker Conjugates for ADC
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/apn-peg5-vc-pab-mmae.html
Purity
95.19
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@@H](NC([C@@H](NC(CCOCCOCCOCCOCCOCC(N=N4)=CN4C5=CC=C(C#CC#N)C=C5)=O)C(C)C)=O)CCCNC(N)=O)=O)=O)=O)=O)=O)OC)=O
Molecular Formula
C81H120N14O18
Molecular Weight
1577.90
References & Citations
[1]Bratti M, et al. INA03, a potent transferrin-competitive antibody-drug conjugate against CD71, for a safer acute leukemia treatment. Mol Cancer Ther. 2024 Apr 20.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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