CAMK1D-IN-1

CAMK1D-IN-1 (compound I) is an inhibitor of CAMK1D, targeting cytotoxic T lymphocyte (CTL) -resistant tumor cells. CAMK1D impairs CTL-induced death receptor signaling and apoptosis by inhibiting caspases, making it a key and effective target for PD-L1-refractory tumors[1].

Product Specifications

CAS Number

[404828-08-6]

UNSPSC

12352005

Target

CaMK

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/camk1d-in-1.html

Purity

99.06

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CC1=CC(NC2=NC(C3=CC=CC=C3)=NC4=C2CCCC4)=NN1

Molecular Formula

C18H19N5

Molecular Weight

305.38

References & Citations

[1]Valentina Volpin, et al. Intracellular kinase associated with resistance against t-cell mediated cytotoxicity, and uses thereof. WO2021229105A1. 2021-05-17