IFNAR-1 mAb (MAR1-5A3), InVivoPure
Anti-IFNAR-1 (clone MAR1-5A3) is a mouse monoclonal antibody targeting the extracellular domain of the murine interferon alpha/beta receptor subunit 1 (IFNAR-1) . It is widely used to block type I interferon signaling in both in vitro and in vivo models. The antibody was developed by immunizing mice via hydrodynamic transfection, a method that induces strong immune responses against membrane proteins. MAR1-5A3 has been shown to effectively inhibit IFN-α/β signaling, making it a valuable tool in studies of viral pathogenesis, autoimmune diseases, and tumor immunology . It is used in neutralization assays, flow cytometry, and functional studies to dissect the role of type I IFNs in immune responses.
Product Specifications
Product Name Alternative
UniProt
P33896
Reactivity
Mouse
Immunogen
Extracellular domain of murine IFNAR1
Target
IFNAR-1, MAR1-5A3, CD118
Clonality
Monoclonal
Clone
MAR1-5A3
Conjugation
Unconjugated
Concentration
≥ 1 mg/ mL
Purity
≥ 90 % (CGE, reducing conditions) ≤ 10 % aggregates (analytical SEC) Endotoxin level ≤ 2 EU/mg
Form
Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Recomended Isotype: Mouse IgG1ĸ Isotype Control, Recomended Isotype Catalog: orb2568796
Tested Applications
ELISA, FC, WB
Host or Source
Mouse
Isotype
Mouse IgG1
Available Sizes
Frequently Asked Questions
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