TGF-β mAb (1D11.16.8), InVivoPure+

The 1D11.16.8 antibody (HB-9849TM) is a mouse monoclonal antibody directed against transforming growth factor-beta (TGF-β) isoforms 1, 2, and 3. TGF-β is a multifunctional cytokine involved in the regulation of proliferation and differentiation of various cell types, including epithelial cells, endothelial cells, fibroblasts, neurons, and immune cells such as T lymphocytes and natural killer cells. This antibody is known for its ability to neutralize TGF-β activity, making it a valuable tool in both in vitro and in vivo studies. It has been shown to significantly improve outcomes in models of advanced pancreatic cancer by inhibiting TGF-β, resulting in reduced mortality, weight loss and muscle wasting. The 1D11.16.8 antibody is highly specific and reacts with TGF-β in multiple species, including humans, mice, rats, monkeys, hamsters, dogs and cows. It is commonly used in research applications such as Western blotting, immunohistochemistry, and functional assays to study the role of TGF-β in various biological processes and diseases.