(±) -Evodiamine

(±) -Evodiamine, a quinazolinocarboline alkaloid, is a Top1 inhibitor. Evodiamine exhibits anti-inflammatory, antiobesity, and antitumor effects. (±) -Evodiamine inhibits the proliferation of a wide variety of tumor cells by inducing their apoptosis[1].

Product Specifications

CAS Number

[518-18-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Topoisomerase

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/racemic-evodiamine.html

Purity

99.97

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=CC=CC=C2N(C)C(N1CC3)C4=C3C5=CC=CC=C5N4

Molecular Formula

C19H17N3O

Molecular Weight

303.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Dong G, et, al. New tricks for an old natural product: discovery of highly potent evodiamine derivatives as novel antitumor agents by systemic structure-activity relationship analysis and biological evaluations. J Med Chem. 2012 Sep 13;55 (17) :7593-613.