XL413 (monohydrochloride)
XL413 (BMS-863233) hydrochloride is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC50 of 3.4 nM, and also shows potent effect with IC50s of 215, 42 nM on CK2, PIM1, respectively, and an EC50 of 118 nM on pMCM.
Product Specifications
CAS Number
2062200-97-7
Product Name Alternative
BMS-863233 (monohydrochloride)
UNSPSC
12352005
Hazard Statement
H301
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xl413-monohydrochloride.html
Purity
99.65
Solubility
DMSO : 3.4 mg/mL (ultrasonic; warming) |H2O : 10 mg/mL (ultrasonic)
Smiles
O=C1C(OC2=CC=C(Cl)C=C23)=C3N=C([C@H]4NCCC4)N1.[H]Cl
Molecular Formula
C14H13Cl2N3O2
Molecular Weight
326.18
Precautions
H301
References & Citations
[1]Koltun ES, et al. Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg Med Chem Lett. 2012 Jun 1;22 (11) :3727-31.|[2]Sasi NK, et al. The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS One. 2014 Nov 20;9 (11) :e113300.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDC
Citation 01
Am J Physiol Lung Cell Mol Physiol. 2018 Sep 1;315 (3) :L360-L370.|Harvard Medical School LINCS LIBRARY|Science. 2017 Dec 1;358 (6367) :eaan4368.|Sens Actuators B Chem. 15 May 2022, 131618.|University of Washington. 2025.|MedComm (2020) . 2025 May 15;6 (6) :e70150.
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