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A-485

Product Specifications

UNSPSC Description

A-485 is a potent and selective catalytic inhibitor of p300/CBP with IC50s of 9.8?nM and 2.6?nM for p300 and CBP histone acetyltransferase (HAT), respectively[1].

Target Antigen

Epigenetic Reader Domain; Histone Acetyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/A-485.html

Purity

99.87

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(N1CC(N([C@@H](C)C(F)(F)F)CC2=CC=C(F)C=C2)=O)[C@]3(OC1=O)C4=CC=C(NC(NC)=O)C=C4CC3

Molecular Weight

536.48

References & Citations

[1]Lasko LM, et al. Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours. Nature. 2017 Oct 5;550(7674):128-132.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-107455/A-485-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-107455/A-485-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

1889279-16-6

Available Sizes

Curated Selection

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