A 419259 (trihydrochloride)
A 419259 trihydrochloride is a Src family kinases inhibitor with IC50s of 9 nM, 3 nM and 3 nM for Src, Lck and Lyn, respectively[1][2].
Product Specifications
CAS Number
1435934-25-0
Product Name Alternative
RK 20449 trihydrochloride
UNSPSC
12352005
Target
Apoptosis; Src
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/A-419259-trihydrochloride.html
Purity
98.28
Solubility
DMSO : 1 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
Smiles
NC1=C2C(N([C@H]3CC[C@H](N4CCN(C)CC4)CC3)C=C2C5=CC=C(OC6=CC=CC=C6)C=C5)=NC=N1.[H]Cl.[H]Cl.[H]Cl
Molecular Formula
C29H37Cl3N6O
Molecular Weight
592.00
References & Citations
[1]Wilson MB, et al. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene. 2002 Nov 21;21 (53) :8075-88.|[2]Zhang X, et al. Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells. Stem Cell Res. 2014 Nov;13 (3 Pt A) :379-89.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Adv Sci (Weinh) . 2025 Jun 30:e17764.|Blood. 2016 Jun 23;127 (25) :3237-52.|Free University of Berlin. 2025 Aug 4.|J Med Chem. 2024 Nov 28;67 (22) :20571-20579.|Microb Pathog. 2024 Dec 25:199:107252.|Patent. US20170333436A1.|Patent. US20250228856A1.
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