A 419259 (trihydrochloride)

A 419259 trihydrochloride is a Src family kinases inhibitor with IC50s of 9 nM, 3 nM and 3 nM for Src, Lck and Lyn, respectively[1][2].

Product Specifications

CAS Number

[1435934-25-0]

Product Name Alternative

RK 20449 trihydrochloride

UNSPSC

12352005

Target

Apoptosis; Src

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/A-419259-trihydrochloride.html

Purity

98.28

Solubility

DMSO : 1 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

NC1=C2C(N([C@H]3CC[C@H](N4CCN(C)CC4)CC3)C=C2C5=CC=C(OC6=CC=CC=C6)C=C5)=NC=N1.[H]Cl.[H]Cl.[H]Cl

Molecular Formula

C29H37Cl3N6O

Molecular Weight

592.00

References & Citations

[1]Wilson MB, et al. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene. 2002 Nov 21;21 (53) :8075-88.|[2]Zhang X, et al. Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells. Stem Cell Res. 2014 Nov;13 (3 Pt A) :379-89.