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IRF5-IN-1

IRF5-IN-1 (Compound C5) is a conformationally locked inhibitor for SLC15A4. IRF5-IN-1 blocks the downstream IRF5 activation, inhibits the TLR7/8 signaling pathway. IRF5-IN-1 exhibits anti-inflammatory responses[1].

Product Specifications

CAS Number

[689270-18-6]

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/irf5-in-1.html

Purity

99.91

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C(NCCCN1CCCCC1C)C2=CC(C3=CC=C(OCC)C=C3)=NC4=CC=CC=C42

Molecular Formula

C27H33N3O2

Molecular Weight

431.57

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

References & Citations

[1]Andras Boeszoermenyi, et al. A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity. Nat Commun. 2023 Oct 20;14 (1) :6626.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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