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SCH 351591

SCH 351591 is a potent, selective and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 58 nM. SCH 351591 can inhibit all 4 PDE4 subtypes (A, B, C, and D) . SCH 351591 has the potential for the asthma and chronic obstructive pulmonary disease (COPD) research[1].

Product Specifications

CAS Number

444659-43-2

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sch-351591.html

Purity

99.22

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=C2C=CC(C(F)(F)F)=NC2=C(OC)C=C1)NC3=C(Cl)C=[N+]([O-])C=C3Cl

Molecular Formula

C17H10Cl2F3N3O3

Molecular Weight

432.18

References & Citations

[1]Patricia E Losco, et al. The toxicity of SCH 351591, a novel phosphodiesterase-4 inhibitor, in Cynomolgus monkeys. Toxicol Pathol. 2004 May-Jun;32 (3) :295-308.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

PDE4

Available Sizes

Frequently Asked Questions

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