ARD-2128
ARD-2128 is a highly potent, orally bioavailable PROTAC androgen receptor (AR) degrader. ARD-2128 effectively reduces AR protein, suppresses AR-regulated genes in tumor tissues, and inhibits growth of tumor without signs of toxicity. ARD-2128 has the potential for the research of the prostate cancer[1].
Product Specifications
CAS Number
2222111-87-5
UNSPSC
12352005
Target
Androgen Receptor; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ard-2128.html
Purity
99.40
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@H]1C(C)(C)[C@H](OC2=CC=C(C#N)C(Cl)=C2)C1(C)C)C3=CC=C(N4CCN(CC5CCN(C6=CC7=C(C(N(C(CC8)C(NC8=O)=O)C7=O)=O)C=C6)CC5)CC4)C=C3
Molecular Formula
C45H50ClN7O6
Molecular Weight
820.37
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
CD44 Standard (156-3C11), CF405S conjugate, 0.1mg/mL
Tyrosinase (T311 + OCA1/812), CF647 conjugate, 0.1mg/mL
![Acetyl CoA synthetase (ACSS2) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI3H4]](https://cdn.genprice.uk/products/937/6868c34d994c49e6dc3f3b7e/imageurl/ta503609am.webp)
Acetyl CoA synthetase (ACSS2) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI3H4]
![PE/Elab Fluor® 594 Mouse IgG2b, κ Isotype Control[MPC-11]](https://cdn.genprice.uk/products/763/68dd1497061270361e7cdf17/imageurl/e-ab-f09813p.webp)