Ac-FLTD-CMK

Ac-FLTD-CMK, a gasdermin D (GSDMD) -derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against caspases-1 (IC50 of 46.7 nM), caspases-4 (IC50 of 1.49 μM), caspases-5 (IC50 of 329 nM), and caspases-11 , but not the apoptotic caspases such as caspase-3[1].

Product Specifications

CAS Number

[2376255-48-8]

UNSPSC

12352005

Target

Caspase; Pyroptosis

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ac-fltd-cmk.html

Purity

99.18

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClCC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](CC(C)C)NC([C@@H](NC(C)=O)CC1=CC=CC=C1)=O)=O)=O)=O

Molecular Formula

C26H37ClN4O8

Molecular Weight

569.05

References & Citations

[1]Jie Yang, et al. Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc Natl Acad Sci U S A. 2018 Jun 26;115 (26) :6792-6797.